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KMID : 1123920030170061468
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 6 p.1468 ~ p.1474
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Experimental Effects of Taklidanggui-tang on the Anti-Cancer and Immuno-Action
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Park In-Su
Yang Seung-Jung
Jo Sung-Hee
Jung Hyun-Woo
Jin Cheon-Sik
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Abstract
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Taklidanggui-tang was a drug that treated carbuncle and cellulitis. So, the purpose of this Study was to investigate effect of Taklidanggui-tang on the anti-cancer and proliferation of immunocytes, nitric oxide(NO) production of peritoneal macrophages. We used Taklidanggui-tang extract(TDT) with freeze-dried, 8wks-old male mice, and L1210 cell lines for this Study. The proliferation of cells was tested using a colorimetric tetrazoliun assay(MTT assay). The results of this Study were obtained as follow ; TDT was showed cytotoxicity on the L1210 cell lines, increased significantly proliferation of thymocytes and splenocytes in vitro. TDT inhibited significantly proliferation of L1210 cells, increased significantly proliferation of immunocytes in L 1210 cells transplanted mice. And TDT was extended significantly mean survival days in 5-180 cells transplanted mice, but TDT did not increased NO production from peritoneal microphages in L1210 cells transplanted mice. This results suggest that TDT has anti-cancer and immuno-action.
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KEYWORD
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Taklidanggui-tang(托裏當歸湯), anti-cancer, proliferation of immunocytes, nitric oxide(NO), MTT assay
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